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Date: 2019-12-30

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2005

Lentiviral siRNAs targeting multiple 
highly conserved RNA sequences 
of human immunodeficiency virus 
type 1.  

Gene Therapy 12, 1133-44.

*Chang, L.-J., 
Liu, X. and He. J

2006

An effective cancer vaccine 
modality: lentiviral modification 
of dendritic cells expressing 
multiple cancer-specific antigens.

Vaccine 24, 3477-89

Wang, B, He, J., 
Chen, L. and 
*Chang, L.-J.

2007

Overlapping enhancer/promoter 
and transcriptional termination 
signals in the lentiviral long 
terminal repeat.

Retrovirology 4:4

Yang, Q, Lucas, 
A., Son, S. and 
*Chang, L.-J.

2008

Overcoming immune tolerance 
against multiple myeloma with 
lentiviral calnexin-engineered 
dendritic cells.

Molecular Therapy 16, 
269-279

Han, S., Wang, 
B., Yang, L.-J., 
Zucali, JR, Moreb,
 JS, and 
*Chang, L.-J.

2009

Lentiviral calnexin-modified 
dendritic cells promote expansion 
of high-avidity effector T cells 
with central memory phenotype.

Immunology 128, 43-57

Wang, B., Han, 
S., Lien, L., 
Guo, L. and 
*Chang, L.-J.

2010

Adoptive transfer of 
cytomegalovirus (CMV) 
/Epstein-Barr virus (EBV)-specific 
immune effector cells 
for therapeutic and preventive
/preemptive treatment of 
pediatric allogeneic cell 
transplant recipients.

Journal of Pediatric 
Hematology/Oncology 32, 
e31-e37.

Dong L, Gao Z,
 *Chang L-J, et al.

2010

Ex vivo development, 
expansion and in vivo 
analysis of a novel lineage 
of dendritic cells from 
hematopoietic stem cells.

J Immune Based Therapies and 
Vaccines 8, 8.

Han S, Wang B,
 Patel ES, 
Okada, S, 
Yang L-J, Moreb 
JS and *Chang L-J

2012

Synergistic effects of 
interleukin-7 and pre-TCR 
signaling in human T cell 
development.

J Biol Chem 287, 33826-35

Patel ES and 
*Chang L-J.

2012

Transition from colitis to 
cancer: high Wnt activity 
sustains the tumor-initiating 
potential of colon cancer stem 
cell precursors. 

Cancer Res 72:5091-5100.

Shenoy AK, 
Butterworth EA,
 Fisher RC, Pi L, 
Chang L-J, 
Appelman HD, 
Chang M, 
Scott EW, 
and *Huang EH.

2013

Transdifferentiation of 
fibroblasts to myocytes via 
bacterial injection of MyoD 
protein. 

Cellular Reprogramming 
15:117-125.

Bichsel C, 
Neeld D, 
Hamazaki T, 
Chang L-J, 
Yang L-J, 
Terada N 
and *Jin S

2015

Stat3 signaling contributes to 
the high effector activities of 
interleukin-15-derived dendritic 
cells. 

Immunol Cell Biol 93: 461-471.  

Okada S, 
Han S, 
Patel ES, 
Yang L-J, 
and *Chang L-J

2015 Immunotherapy for multiple myeloma:
Current status and future directions.

Crit Rev Oncol Hematol. 2015 Dec;
96(3):399-412
Ayed AO,  Chang LJ, 
Moreb JS

2016

Motion acupuncture for 
musculoskeletal pain: 
principles and methods. 
 

European Journal of BioMedical 
Research, 2016, 2(2): 19-24.

Chen D, 
Yang G, 
Chen X, et al. 

2017

Significant and sustaining 
elevation of blood oxygen 
induced by Chinese cupping 
therapy as assessed by near
-infrared spectroscopy.

Biomedical optics express, 2017, 
8(1): 223-229.

Li T, Li Y, 
Lin Y, et al.

2018

Sequential allogeneic and 
autologous CAR-T cell therapy 
to treat an immune compromised 
leukemic patient. 

Blood Advances 2, 1691-1695

Zhang J-P, 
Zhang R, 
Tsao S-T, 
Liu Y-C, 
Chen X,
 Lu D-P, 
Castillo P 
and Chang L-J

2018

Phase I/II Trial of Multi-Target Chimeric Antigen Receptor Modified T Cells (4SCAR2.0) Against Relapsed or Refractory Lymphomas

Blood (2018) 132 (Supplement 1): 225.

Lung-Ji Chang,  Yuhua Li,  Sanfang Tu,    Xun Lai,    Rui Huang,  Shih-Ting Tsao,    Yu-Chen Liu,  Rui Zhang,  Lan Deng,    Xuan Zhou,  Hongyu Zhang,  Wenli Zhang,    Yuchen Li

2018 CD70 as a target for chimeric antigen 
receptor T cells in head and neck 
squamous cell carcinoma.

Oral Oncol. 2018 Mar;
78:145-150.
Park YP;Jin L;
Bennett KB; Wang D;
Fredenburg KM;
Tseng JE;Chang LJ; 
Huang J;Chan EKL.
2019
Adoptive immunotherapy for 
B-cell malignancies using 
CD19-targeted chimeric 
antigen receptor T-cells: 
A systematic review of efficacy 
and safety.

Current Medicinal Chemistry, 2019.
Hao L, Li T,
 Chang L J, et al.
2019

Shortening the ex vivo culture of 
CD19-specific CAR T-cells retains 
potent efficacy against acute 
lymphoblastic leukemia without 
CAR T-cell-related encephalopathy 
syndrome or severe cytokine release 
syndrome.

Am J Hematol. 2019

Tu S, Huang R, 
Guo Z, Deng L, 
Song C, Zhou X, 
Yue C, Zhang L, 
He Y, Yang J1, 
Liang Z, Du J, 
Cao P, Li Y, 
Chang LJ, Li Y.


2019

Chimeric antigen receptors T cells 

for treatment of 48 relapsed or 
refractory acute lymphoblastic 
leukemia children: long term 
follow-up outcome.

中华血液学杂志;40(4):270-275.
左英熹 , 
贾月萍 , 吴珺 , 
王静波 , 陆爱东 , 
董陆佳 , 张隆基 , 
张乐萍
2019 Functional Improvement of 
Chimeric Antigen Receptor 
Through Intrinsic 
Interleukin-15Rα Signaling.

Curr Gene Ther. 2019;19(1):40-53.
Nair S, Wang JB, 
Tsao ST, Liu Y, 
Zhu W, Slayton WB,
Moreb JS, Dong L, 
Chang LJ.
2019 CD19 and CD70 Dual-Target Chimeric 
Antigen Receptor T-Cell Therapy for 
the Treatment of Relapsed and 
Refractory Primary Central Nervous 
System Diffuse Large B-Cell Lymphoma.

Front Oncol. 2019; 9: 1350.
Sanfang Tu, Xuan Zhou, 
Zhenling Guo, Rui Huang, 
Chunyan Yue, Yanjie He,
Meifang Li, Yiran Chen,
YuChen Liu, Lung-ji Chang 
and Yuhua Li.
2019 CD56–chimeric antigen receptor T-cell
therapy for CD56–chimeric antigen
receptor T-cell therapy for refractory
/recurrent rhabdomyosarcoma.

Medicine (2019) 98:43
Chiyi Jiang, Wen Zhao,
Maoquan Qin, Mei Jin,
Lungji Chang, Xiaoli Ma
2019
Hemophilia Gene Therapy: New Development from Bench to Bed Side
Current Gene Therapy. 2019; 19: 264-273.
Xiao-Lu Guo, Tsai-Hua Chung, Yue Qin, Lung-Ji Chang et al
2020
Successful Anti-CLL1 CAR T-Cell Therapy in Secondary Acute Myeloid Leukemia
Front. Oncol, 2020
Hui Zhang, Wen-Ting Gan, Wen-Ge Hao1, Peng-Fei Wang, Zhuo-Yan Li and Lung-Ji Chang
2020
GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma – assessing tumor and T cell interaction
Transl Oncol 14 (2): 100971.
Jatuporn Sujjitjoon, Elias Sayour, Shih-Ting Tsao, Mongkol Uiprasertkul, Kleebsabai Sanpakit, Jassada Buaboonnam, Pa-thai Yenchitsomanus, La-ongsri Atchaneeyasakul, and Lung-Ji Chang
2020
GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas
Am J Cancer Res 2020;10(2):674-687
Monrat Chulanetra, Atthapan Morchang , Elias Sayour, Lamis Eldjerou, Rowan Milner , Joanne Lagmay , Matt Cascio , Brian Stover , William Slayton , Wanpen Chaicumpa, Pa-Thai Yenchitsomanus , Lung-Ji Chang
2020
4SCAR-GD2-modified T-cell therapy in neuroblastoma with MYCN amplification: A case report with over 4-year follow-up data
Pediatr Invest 2020 Mar; 4 (1): 55-58
Xiao Xu, Wen Zhao, Zhixia Yue, Maoquan Qin, Mei Jin
Lung-Ji Chang, Xiaoli Ma
2021
GD2‑specifc chimeric antigen receptor‑modifed T cells for the treatment of refractory and/or recurrent neuroblastoma in pediatric patients
Journal of Cancer Research and Clinical Oncology
Lihua Yu,  Lulu Huang, Danna Lin ,  Xiaorong Lai ,  Li Wu · Xu Liao, Jiale Liu ,  Yinghua Zeng , Lichan Liang ,  Guanmei Zhang , Bin Wang , Zhu Wu ,  Shaohua Tao , Yuchen Liu ,  Cheng Jiao ,  Lung‑Ji Chang , Lihua Yang
2021

4SCAR2.0: a multi-CAR-T therapy regimen for the

treatment of relapsed/refractory B cell lymphomas


Blood Cancer 1159.
Cheng Jiao1, Eugene Zvonkov, Xun Lai, Rui Zhang, Yuchen Liu1, Yue Qin, Valery Savchenko, Nelly Gabeeva, Tsai-Hua Chung, Liyuan Sheng and Lung-Ji Chang
2021
4SCAR2.0 Treating Refractory B Cell Lymphomas: An Advanced Technology Saves More Lives
iMedPub Journals 7:3.
Jiao C, Sheng L, Chang L-J
2021
A Glimpse into the Diverse Cellular Immunity against SARS-CoV-2
Vaccines 9: 827.
Cheng-Wei Chang, Yuchen Liu, Cheng Jiao, Hongwei Liu, Jie Gong, Xiaochuan Chen and Lung-Ji Chang
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