A 28 year-old woman with Hodgkin's lymphoma…

Cancer History:

First diagnosis of cancer: 2011   Cancer type: Hodgkin’s Lymphoma nodular sclerosis, stage IIIa

First recurrence date: 01.2016     Sites: liver, abdomen, LN

Refractory or persistent disease sites: liver, abdomen, lung, LN, hepatosplenomegaly

Therapy gone through: Surgery: No

Chemotherapy 8 cycles, 4 ABVD, 4 BVD regimen, gemcitabine;

Radiotherapy: yes, post-radiatherapy pulmonary fibrosis; ABMT: 5.2016

Targeted drugs: bendamustine   Immunotherapy: Brentuximab, Nivoluma   others:

Clinical Trial Number: NCT02274584 (4SCAR30273); enrolled date: 18/07/2019

Interventions: 4SCAR (CD19, CD22, PSMA)

Consolidation: EIE

CRS Grade:1 ; other side effects:  knee joint pain

Treatment response: PR     Quality of Life: improved

Progression-free interval: 2 months

Current status: Alive with disease

Disease images before and after CART/EIE treatment (with time)